Attenuation of Hippocampal Evoked Potentials in vivo by Activation of GtACR2, an Optogenetic Chloride Channel

Attenuation of Hippocampal Evoked Potentials in vivo by Activation of GtACR2, an Optogenetic Chloride Channel

AimGtACR2, a light-activated chloride channel, is an attractive tool for neural inhibition as it can shunt membrane depolarizations. In this study, we assessed the effect of activating GtACR2 on in vivo hippocampal CA1 activity evoked by Schaffer collateral (SC) stimulation.MethodsAdult male Wistar...

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Bibliographic Details
Main Authors: Anirudh R. Acharya, Lars Emil Larsen, Wouter Van Lysebettens, Wytse Jan Wadman, Jean Delbeke, Kristl Vonck, Alfred Meurs, Paul Boon, Robrecht Raedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
hippocampus
CA1 inhibition
GtACR2
chloride channel
optogenetics
evoked potential
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.653844/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.653844/full

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