Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome

Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome

The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic system, a presynaptic hyperdopaminergic state, seem to be involved in PLMS, while alterations in glutamatergic neurotransmission, a...

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Bibliographic Details
Main Authors: Sergi Ferré, César Quiroz, Xavier Guitart, William Rea, Arta Seyedian, Estefanía Moreno, Verònica Casadó-Anguera, Manuel Díaz-Ríos, Vicent Casadó, Stefan Clemens, Richard P. Allen, Christopher J. Earley, Diego García-Borreguero
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Neuroscience
Subjects:
Restless Legs Syndrome
periodic leg movements during sleep
hyperarousal
dopamine
glutamate
adenosine
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00722/full

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http://journal.frontiersin.org/article/10.3389/fnins.2017.00722/full

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