Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Formaldehyde Induces Mesenteric Artery Relaxation via a Sensitive Transient Receptor Potential Ankyrin-1 (TRPA1) and Endothelium-Dependent Mechanism: Potential Role in Postprandial Hyperemia

Formaldehyde (FA), the smallest aldehyde, is generated endogenously, and is widespread in the environment in foods, beverages and as a gas phase product of incomplete combustion. The main metabolite of FA, formate, was increased significantly in murine urine (∼3×) after overnight feeding. Because fe...

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Bibliographic Details
Main Authors: L. Jin, G. Jagatheesan, L. Guo, M. Nystoriak, M. Malovichko, P. Lorkiewicz, A. Bhatnagar, S. Srivastava, D. J. Conklin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
aldehydes
EDRF
formalin
mesenteric artery
nitric oxide
transient receptor potential ankyrin-1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00277/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00277/full

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