Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma

Abstract Background Activating Gαq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT2R) forms a rare alternative. The role of wild-type CysLT2R in uveal...

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Bibliographic Details
Main Authors: Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager, Pieter A. van der Velden
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
CYSLTR2
Uveal nevus
Uveal melanoma
Digital PCR
Heterogeneity
Online Access:https://doi.org/10.1186/s12885-021-07865-x

Internet

https://doi.org/10.1186/s12885-021-07865-x

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