Epigenetic silencing of miR‐1271 enhances MEK1 and TEAD4 expression in gastric cancer

Epigenetic silencing of miR‐1271 enhances MEK1 and TEAD4 expression in gastric cancer

Abstract Epigenetic dysregulation is a major driver of tumorigenesis. To identify tumor‐suppressive microRNAs repressed by DNA methylation in gastric cancer (GC), we analyzed the genome‐wide DNA methylation and microRNA expression profiles of EpCAM+/CD44+ GC cells. Among the set of microRNAs screene...

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Bibliographic Details
Main Authors: Byungho Lim, Hee‐Jin Kim, Haejeong Heo, Nanhyung Huh, Su‐Jin Baek, Jong‐Hwan Kim, Dong‐Hyuck Bae, Eun‐Hye Seo, Sang‐Il Lee, Kyu‐Sang Song, Seon‐Young Kim, Yong Sung Kim, Mirang Kim
Format: Article
Language:English
Published: Wiley 2018-07-01
Series:Cancer Medicine
Subjects:
DNA methylation
gastric cancer
MEK1
miR‐1271
TEAD4
Online Access:https://doi.org/10.1002/cam4.1605

Internet

https://doi.org/10.1002/cam4.1605

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