Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like do...

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Bibliographic Details
Main Authors: Ravi Kant, Baisen Zeng, Celestine J Thomas, Brian Bothner, Stephen R Sprang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
heterotrimeric G proteins
non-receptor guanine nucleotide exchange factor
hydrogen-deuterium exchange mass spectrometry
protein secondary structure
protein dynamics
Online Access:https://elifesciences.org/articles/19238

Internet

https://elifesciences.org/articles/19238

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