The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer.

The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer.

BACKGROUND:Circulating angiogenic factors are altered in patients with mCRC receiving bevacizumab. Evaluation of alterations in levels of VEGF ligands may provide insights into possible resistance mechanisms. METHODS:PlGF, VEGF-A, VEGF-C, and VEGF-D were measured from two cohorts of patients. Sequen...

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Bibliographic Details
Main Authors: Christopher H Lieu, Hai Tran, Zhi-Qin Jiang, Muling Mao, Michael J Overman, E Lin, Cathy Eng, Jeffrey Morris, Lee Ellis, John V Heymach, Scott Kopetz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797099?pdf=render

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http://europepmc.org/articles/PMC3797099?pdf=render

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