Functional Characterization of a Missense Variant of MLH1 Identified in Lynch Syndrome Pedigree

Functional Characterization of a Missense Variant of MLH1 Identified in Lynch Syndrome Pedigree

Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRCs) inherited in an autosomal-dominant manner. Here, we reported a multigeneration Chinese family clinically diagnosed with LS according to the Amsterdam II criteria. To identify the underlying causative gene for LS in this famil...

Full description

Bibliographic Details
Main Authors: Tahir Zaib, Chunhui Zhang, Komal Saleem, Lidan Xu, Qian Qin, Yusi Wang, Wei Ji, Hanif Khan, Hanfei Yu, Siqi Zhu, Wei Gao, Yun Huang, Xueyuan Jia, Jie Wu, Hongtao Song, Yanqiao Zhang, Wenjing Sun, Songbin Fu
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2020/8360841

Internet

http://dx.doi.org/10.1155/2020/8360841

Similar Items