The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8

The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8

Although the N-terminal domain of vertebrate small heat shock proteins (sHsp) is poorly conserved, it contains a core motif preserved in many members of the sHsp family. The role of this RLFDQxFG motif remains elusive. We analyzed the specific role of the first arginine residue of this conserved oct...

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Bibliographic Details
Main Authors: Vladislav M. Shatov, Stephen D. Weeks, Sergei V. Strelkov, Nikolai B. Gusev
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
small heat shock proteins
oligomer structure
chaperone-like activity
disease-related mutations
Online Access:http://www.mdpi.com/1422-0067/19/7/2112

Internet

http://www.mdpi.com/1422-0067/19/7/2112

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