Computational Design of Nitrile Hydratase from <i>Pseudonocardia thermophila</i> JCM3095 for Improved Thermostability

Computational Design of Nitrile Hydratase from <i>Pseudonocardia thermophila</i> JCM3095 for Improved Thermostability

High thermostability and catalytic activity are key properties for nitrile hydratase (NHase, EC 4.2.1.84) as a well-industrialized catalyst. In this study, rational design was applied to tailor the thermostability of NHase from <i>Pseudonocardia thermophila</i> JCM3095 (<i>Pt</i...

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Bibliographic Details
Main Authors: Zhongyi Cheng, Yao Lan, Junling Guo, Dong Ma, Shijin Jiang, Qianpeng Lai, Zhemin Zhou, Lukasz Peplowski
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
Nitrile hydratase
NHase
thermostability
catalytic activity
rational design
bioengineering
Online Access:https://www.mdpi.com/1420-3049/25/20/4806

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https://www.mdpi.com/1420-3049/25/20/4806

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