Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Accordingly, ADCC and ADCP induced by anti-HIV envelope gp120 IgG have been correlated to the limite...

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Bibliographic Details
Main Authors: Maxence Duchemin, Daniela Tudor, Andréa Cottignies-Calamarte, Morgane Bomsel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
IgA
HIV-1 envelope gp41
phagocytosis
ADCP
FcαRI/CD89
neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01141/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01141/full

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