Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors

Twenty-three thiazolin-4-ones were synthesized starting from phenylthioamide or thiourea derivatives by condensation with α-monochloroacetic acid or ethyl α-bromoacetate, followed by substitution in position 5 with various arylidene moieties. All the synthesized compounds were physico-chemically cha...

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Bibliographic Details
Main Authors: Anca Stana, Dan C. Vodnar, Radu Tamaian, Adrian Pîrnău, Laurian Vlase, Ioana Ionuț, Ovidiu Oniga, Brînduşa Tiperciuc
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
thiazolin-4-one
antifungal activity
lipophilicity
lanosterol 14α-demethylase
molecular docking
ADME-Tox predictors
Online Access:http://www.mdpi.com/1422-0067/18/1/177

Internet

http://www.mdpi.com/1422-0067/18/1/177

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