Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis

Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis

Genomic instability plays a key role in driving cancer development. It is already found in precancerous lesions and allows the acquisition of additional cancerous features. A major source of genomic instability in early stages of tumorigenesis is DNA replication stress. Normally, origin licensing an...

Full description

Bibliographic Details
Main Authors: Dan Sarni, Batsheva Kerem
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:International Journal of Molecular Sciences
Subjects:
oncogene
DNA replication
replication stress
genomic instability
cancer
Online Access:http://www.mdpi.com/1422-0067/18/7/1339

Internet

http://www.mdpi.com/1422-0067/18/7/1339

Similar Items