Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis
Genomic instability plays a key role in driving cancer development. It is already found in precancerous lesions and allows the acquisition of additional cancerous features. A major source of genomic instability in early stages of tumorigenesis is DNA replication stress. Normally, origin licensing an...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/18/7/1339 |