Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease

Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease

Abstract Background An important hallmark of Alzheimer’s disease (AD) is the increase of Aβ1-42 burden and its accumulation to senile plaques, leading the reactive gliosis and neurodegeneration. The modulation of glia cell function represents an attractive therapeutic strategy, but is currently limi...

Full description

Bibliographic Details
Main Authors: Nicole Schröder, Anja Schaffrath, Josua A. Welter, Tim Putzka, Angelika Griep, Patrick Ziegler, Elisa Brandt, Sebastian Samer, Michael T. Heneka, Hannes Kaddatz, Jiangshan Zhan, Eugenia Kipp, Thomas Pufe, Simone C. Tauber, Markus Kipp, Lars-Ove Brandenburg
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer disease
Amyloid beta
Formyl peptide receptor
Glia cell
Microglia
Innate immunity
Online Access:http://link.springer.com/article/10.1186/s12974-020-01816-2

Internet

http://link.springer.com/article/10.1186/s12974-020-01816-2

Similar Items