Age Modulates Fe3O4 Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats

Age Modulates Fe3O4 Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats

We examined the effects of iron oxide nanoparticles (IONPs) on mitochondrial respiratory chain complexes activities and mitochondrial coupling in young (3 months) and middle-aged (18 months) rat liver, organ largely involved in body iron detoxification. Isolated liver mitochondria were extracted usi...

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Bibliographic Details
Main Authors: Yosra Baratli, Anne-Laure Charles, Valérie Wolff, Lotfi Ben Tahar, Leila Smiri, Jamal Bouitbir, Joffrey Zoll, Mohsen Sakly, Cyril Auger, Thomas Vogel, Hafedh Abdelmelek, Olfa Tebourbi, Bernard Geny
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/474081

Internet

http://dx.doi.org/10.1155/2014/474081

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