Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio

Frontotemporal dementia is the leading cause of “true” A−/T+ profiles defined with Aβ42/40 ratio

Abstract Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical...

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Bibliographic Details
Main Authors: Hélène Pouclet‐Courtemanche, Tri‐Bao Nguyen, Emilie Skrobala, Claire Boutoleau‐Bretonnière, Florence Pasquier, Elodie Bouaziz‐Amar, Edith Bigot‐Corbel, Susanna Schraen, Julien Dumurgier, Claire Paquet, Thibaud Lebouvier
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
Cerebrospinal fluid biomarkers
Aβ42/40 ratio
Aβ42/Aβ40 ratio
Frontotemporal dementia
Suspected non Alzheimer's disease pathology (SNAP)
Online Access:https://doi.org/10.1016/j.dadm.2019.01.001

Internet

https://doi.org/10.1016/j.dadm.2019.01.001

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