Myeloid Cell Crosstalk Regulates the Efficacy of the DNA/ALVAC/gp120 HIV Vaccine Candidate

Myeloid Cell Crosstalk Regulates the Efficacy of the DNA/ALVAC/gp120 HIV Vaccine Candidate

Vaccination with DNA-SIV + ALVAC-SIV + gp120 alum results in inflammasome activation, high levels of IL-1β production, emergency myelopoiesis, and the egress of CXCR4+ CD14+ pre-monocytes from bone marrow. Previously we have shown that this vaccine-induced innate monocyte memory is associated with d...

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Bibliographic Details
Main Authors: Monica Vaccari, Slim Fourati, Dallas R. Brown, Isabela Silva de Castro, Massimiliano Bissa, Luca Schifanella, Melvin N. Doster, Kathryn E. Foulds, Mario Roederer, Richard A. Koup, Yongjun Sui, Jay A. Berzofsky, Rafick-Pierre Sekaly, Genoveffa Franchini
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
MDSC
trained immunity
myeloid cells
HIV/SIV
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01072/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01072/full

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