Siah2 control of T-regulatory cells limits anti-tumor immunity

Siah2 control of T-regulatory cells limits anti-tumor immunity

The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressive regulatory T cells, resulting in inhibition of t...

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Bibliographic Details
Main Authors: Marzia Scortegagna, Kathryn Hockemeyer, Igor Dolgalev, Joanna Poźniak, Florian Rambow, Yan Li, Yongmei Feng, Roberto Tinoco, Dennis C. Otero, Tongwu Zhang, Kevin Brown, Marcus Bosenberg, Linda M. Bradley, Jean-Christophe Marine, Ioannis Aifantis, Ze’ev A. Ronai
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13826-7

Internet

https://doi.org/10.1038/s41467-019-13826-7

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