Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture

Constitutive deletion of Rcan1 has been previously shown to prevent Angiotensin II-induced aneurysm in mice. Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to in...

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Bibliographic Details
Main Authors: Silvia Villahoz, Paula Sofía Yunes-Leites, Nerea Méndez-Barbero, Katia Urso, Elena Bonzon-Kulichenko, Sagrario Ortega, J. Francisco Nistal, Jesus Vazquez, Stefan Offermanns, Juan Miguel Redondo, Miguel R. Campanero
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07071-7

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https://doi.org/10.1038/s41467-018-07071-7

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