Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
Constitutive deletion of Rcan1 has been previously shown to prevent Angiotensin II-induced aneurysm in mice. Here the authors show that tissue-specific inducible deletion of Rcan1 in vascular cell types predisposes to hypertension-mediated aortic rupture, intramural hematoma, and aneurysm, due to in...
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Bibliographic Details
Main Authors: |
Silvia Villahoz,
Paula Sofía Yunes-Leites,
Nerea Méndez-Barbero,
Katia Urso,
Elena Bonzon-Kulichenko,
Sagrario Ortega,
J. Francisco Nistal,
Jesus Vazquez,
Stefan Offermanns,
Juan Miguel Redondo,
Miguel R. Campanero |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2018-11-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-07071-7
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