A novel inhibitor, 2-cyano-3-(1-phenyl-3-(thiophen-2-yl)-pyrazol-4-yl)acrylamide linked to sulphamethoxazole, blocks anti-apoptotic proteins via molecular docking and strongly induced apoptosis of HCT116 cell line by different molecular tools

A novel inhibitor, 2-cyano-3-(1-phenyl-3-(thiophen-2-yl)-pyrazol-4-yl)acrylamide linked to sulphamethoxazole, blocks anti-apoptotic proteins via molecular docking and strongly induced apoptosis of HCT116 cell line by different molecular tools

A new series of cyanoacrylamides incorporating sulphamethoxazol were prepared and confirmed by different spectral tools. Anticancer screening of the new compounds was done against three different types of carcinoma cell lines involving (A549, HCT116, and MDA) using MTT assay. Compound 7 among all te...

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Bibliographic Details
Main Authors: Magda F. Mohamed, Heba K.A. Elhakim, Amna A. Saddiq, Ismail A. Abdelhamid
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Arabian Journal of Chemistry
Subjects:
Colorectal carcinoma
Cyanoacrylamides
Sulphamethoxazole
Cytotoxicity
Modeling studies
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220301453

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http://www.sciencedirect.com/science/article/pii/S1878535220301453

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