Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

Summary: Clinical implementation of tumor organoids for personalized medicine requires that pure tumor organoids can be reliably established. Here, we present our experience with organoid cultures from >70 non-small cell lung cancer (NSCLC) samples. We systematically evaluate several methods to i...

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Bibliographic Details
Main Authors: Krijn K. Dijkstra, Kim Monkhorst, Luuk J. Schipper, Koen J. Hartemink, Egbert F. Smit, Sovann Kaing, Rosa de Groot, Monika C. Wolkers, Hans Clevers, Edwin Cuppen, Emile E. Voest
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
organoids
personalized medicine
tumor purity
genomics
p63
non-small cell lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305374

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http://www.sciencedirect.com/science/article/pii/S2211124720305374

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