IL-15 sustains IL-7R-independent ILC2 and ILC3 development
ILC2 and ILC3 are generally thought to require IL-7. Here the authors use IL-7 ko mice and provide side-by-side comparison of ILCs from different tissues to show that IL-7 signalling is not required for intestinal ILC maintenance or function and that IL-15 can compensate for absence of IL-7.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14601 |