Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function

Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function

Glycine receptors (GlyRs) containing the α2 subunit regulate cortical interneuron migration. Disruption of the GlyR α2 subunit gene (Glra2) in mice leads to disrupted dorsal cortical progenitor homeostasis, leading to a depletion of projection neurons and moderate microcephaly in newborn mice. In hu...

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Bibliographic Details
Main Authors: Yan Zhang, Thi Nhu Thao Ho, Robert J. Harvey, Joseph W. Lynch, Angelo Keramidas
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorder
epilepsy
glycine receptor
GLRA2
GlyR α2 subunit
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00158/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00158/full

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