Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Paraventricular hypothalamus mediates diurnal rhythm of metabolism

Defective rhythmic metabolism is associated with high-fat diet feeding and obesity. The authors show that the clock gene BMAL1 drives paraventricular hypothalamic neuron activity via rhythmic GABAergic neurotransmission, and that this mediates diurnal metabolism and diet-induced obesity.

Bibliographic Details
Main Authors: Eun Ran Kim, Yuanzhong Xu, Ryan M. Cassidy, Yungang Lu, Yongjie Yang, Jinbin Tian, De-Pei Li, Rachel Van Drunen, Aleix Ribas-Latre, Zhao-Lin Cai, Mingshan Xue, Benjamin R. Arenkiel, Kristin Eckel-Mahan, Yong Xu, Qingchun Tong
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17578-7

Internet

https://doi.org/10.1038/s41467-020-17578-7

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