Response to HER2 Inhibition in a Patient With Brain Metastasis With EGFR TKI Acquired Resistance and an HER2 Amplification

A 62-year-old man was referred to our university hospital for treatment of advanced adenocarcinoma of the lung after disease progression on two lines of EGFR TKI and one line of chemotherapy. Fluorescent in situ hybridization analysis upon progression showed an HER2 amplification. At our weekly Mole...

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Bibliographic Details
Main Authors: Arenda D. Meedendorp, Arja ter Elst, Nils A. ’t Hart, Harry J. M. Groen, Ed Schuuring, Anthonie J. van der Wekken
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Oncology
Subjects:
TKI
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00176/full