SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Abstract Background Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here,...

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Bibliographic Details
Main Authors: Pamela Becherini, Irene Caffa, Francesco Piacente, Patrizia Damonte, Valerio G. Vellone, Mario Passalacqua, Andrea Benzi, Tommaso Bonfiglio, Daniele Reverberi, Amr Khalifa, Moustafa Ghanem, Ana Guijarro, Luca Tagliafico, Marzia Sucameli, Angelica Persia, Fiammetta Monacelli, Michele Cea, Santina Bruzzone, Silvia Ravera, Alessio Nencioni
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer & Metabolism
Subjects:
SIRT6
Breast cancer
Cancer metabolism
Mammary tumorigenesis
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s40170-021-00240-1

Internet

https://doi.org/10.1186/s40170-021-00240-1

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