Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy

Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a promising approach to improve patient outcomes owin...

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Bibliographic Details
Main Authors: Pavlina Chuntova, Kira M. Downey, Bindu Hegde, Neil D. Almeida, Hideho Okada
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
T lymphocyte
brain cancer
Glioblastoma
TCR - T cell receptor
CAR (chimeric antigen receptor) T cells
Glioma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03062/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03062/full

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