Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin

Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax, contains the effector moiety lethal factor (L...

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Bibliographic Details
Main Authors: Jennifer Bromberg-White, Chih-Shia Lee, Nicholas Duesbery
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Toxins
Subjects:
anthrax
lethal factor
mitogen-activated protein kinase kinase
pathogenesis
metalloprotease
tumorigenesis
retinal neovascularization
Online Access:http://www.mdpi.com/2072-6651/2/5/1038/

Internet

http://www.mdpi.com/2072-6651/2/5/1038/

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