ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

Evolutionary reconstruction algorithms produce models of the evolutionary history of proteins or species. Such algorithms are highly sensitive to their inputs: the sequences used and their alignments. Here, we asked whether the variance introduced by selecting different input sequences could be used...

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Bibliographic Details
Main Authors: Roman Sloutsky, Kristen M Naegle
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/47676