Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammationResearch in context

Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammationResearch in context

Background: Acute lung injury (ALI) is a severe life-threatening inflammatory disease. Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT regulates diverse cellular responses, but the significance in neutrophilic inflammation and ALI remains unknown. Methods: Human...

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Main Authors: Po-Jen Chen, I-Ling Ko, Chia-Lin Lee, Hao-Chun Hu, Fang-Rong Chang, Yang-Chang Wu, Yann-Lii Leu, Chih-Ching Wu, Cheng-Yu Lin, Chang-Yu Pan, Yung-Fong Tsai, Tsong-Long Hwang
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300507

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http://www.sciencedirect.com/science/article/pii/S2352396419300507

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