Bio-Distribution and Pharmacokinetics of Topically Administered γ-Cyclodextrin Based Eye Drops in Rabbits

Bio-Distribution and Pharmacokinetics of Topically Administered γ-Cyclodextrin Based Eye Drops in Rabbits

The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in rabbit eyes. In this randomized, controlled study...

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Bibliographic Details
Main Authors: Martin Kallab, Kornelia Schuetzenberger, Nikolaus Hommer, Bhavapriya Jasmin Schäfer, Doreen Schmidl, Helga Bergmeister, Markus Zeitlinger, Aimin Tan, Phatsawee Jansook, Thorsteinn Loftsson, Einar Stefansson, Gerhard Garhöfer
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
γ-cyclodextrin
irbesartan
candesartan
multiple instillation
single instillation
nanoparticles
Online Access:https://www.mdpi.com/1424-8247/14/5/480

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https://www.mdpi.com/1424-8247/14/5/480

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