The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.

The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss.

Progressive hearing loss is common in the human population, but we have few clues to the molecular basis. Mouse mutants with progressive hearing loss offer valuable insights, and ENU (N-ethyl-N-nitrosourea) mutagenesis is a useful way of generating models. We have characterised a new ENU-induced mou...

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Bibliographic Details
Main Authors: Sarah L Spiden, Mario Bortolozzi, Francesca Di Leva, Martin Hrabé de Angelis, Helmut Fuchs, Dmitry Lim, Saida Ortolano, Neil J Ingham, Marisa Brini, Ernesto Carafoli, Fabio Mammano, Karen P Steel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2568954?pdf=render

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http://europepmc.org/articles/PMC2568954?pdf=render

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