Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

<p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum </it>readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competiti...

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Bibliographic Details
Main Authors: White Nicholas J, Day Nicholas PJ, Songtawee Napat, Theppabutr Sasikrit, Choowongkomon Kiattawee, Woodrow Charles J, Imwong Mallika
Format: Article
Language:English
Published: BMC 2010-03-01
Series:Malaria Journal
Online Access:http://www.malariajournal.com/content/9/1/65

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http://www.malariajournal.com/content/9/1/65

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