Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, i...

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Bibliographic Details
Main Authors: Lisa Pleyer, Peter Valent, Richard Greil
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells (MSC)
myelodysplastic syndromes (MDS)
acute myeloid leukemia (AML)
microenvironment
neoplastic stem cells
bone marrow stem cell niche
leukemic niche
immunomodulation
epithelial-to-mesenchymal transition
endothelial-to-mesenchymal transition
Online Access:http://www.mdpi.com/1422-0067/17/7/1009

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http://www.mdpi.com/1422-0067/17/7/1009

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