Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils

Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils

Abstract Background Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood. The aim of this study is to characterize Tau seeds by their size and seeding capacity. Methods Tau aggregates were is...

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Bibliographic Details
Main Authors: André Marreiro, Kristof Van Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo-Rodriguez, Jan R. T. van Weering, Debby Van Dam, Peter P. De Deyn, Adrian Apetri, Liliane Schoofs, Marc H. Mercken
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Molecular and Cell Biology
Subjects:
Alzheimer’s disease
Tau
Tau aggregation
Aggregation
Seeding
Online Access:http://link.springer.com/article/10.1186/s12860-020-00320-y

Internet

http://link.springer.com/article/10.1186/s12860-020-00320-y

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