Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9

Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9

Abstract Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as a prophylactic (radioprotection) and treatment (ra...

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Bibliographic Details
Main Authors: Craig M. Brackett, Kellee F. Greene, Alyssa R. Aldrich, Nicholas H. Trageser, Srabani Pal, Ivan Molodtsov, Bojidar M. Kandar, Lyudmila G. Burdelya, Scott I. Abrams, Andrei V. Gudkov
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00642-6

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https://doi.org/10.1038/s41420-021-00642-6

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