Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy

Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy

Ras-related C3 botulinum toxin substrate 1 (RAC1) activation plays a vital role in diabetic nephropathy (DN), but the exact mechanism remains unclear. In this study, we attempted to elucidate the precise mechanism of how RAC1 aggravates DN through cellular and animal experiments. In this study, DN w...

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Bibliographic Details
Main Authors: Changjiang Ying, Jiao Dai, Gaoxia Fan, Zhongyuan Zhou, Tian Gan, Yusheng Zhang, Yuanjian Song, Xiaoyan Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
Ras-related C3 botulinum toxin substrate 1
MLK3-MKK7-JNK signal module
diabetic nephropathy
c-Jun N-terminal kinase
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.679166/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.679166/full

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