Identification of active and inactive agonists/antagonists of estrogen receptor based on Tox21 10K compound library: Binomial analysis and structure alert

Endocrine disrupting chemicals can mimic, block, or interfere with hormones in organisms and subsequently affect their development and reproduction, which has raised significant public concern over the past several decades. To investigate (quantitative) structure–activity relationship, 8280 compound...

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Bibliographic Details
Main Authors: Jia Wang, Ying Huang, Shuo Wang, Yi Yang, Jia He, Chao Li, Yuan H. Zhao, Christopher J. Martyniuk
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321002256