DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease

DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease

Huntington disease (HD) is a devastating neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. Disrupted cortico-striatal transmission is an early event that contributes to neuronal spine and synapse dysfunction primarily in striatal medium spiny neurons, the most vulne...

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Bibliographic Details
Main Authors: Mandi E. Schmidt, Nicholas S. Caron, Amirah E. Aly, Fanny L. Lemarié, Louisa Dal Cengio, Yun Ko, Nikola Lazic, Lisa Anderson, Betty Nguyen, Lynn A. Raymond, Michael R. Hayden
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
DAPK1
synaptic
GluN2B
pS1303
Huntington disease
YAC128
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.590569/full

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https://www.frontiersin.org/articles/10.3389/fncel.2020.590569/full

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