A novel method linking antigen presentation by human monocyte-derived macrophages to CD8+ T cell polyfunctionality

A novel method linking antigen presentation by human monocyte-derived macrophages to CD8+ T cell polyfunctionality

To understand the interactions between innate and adaptive immunity, and specifically how virally-infected macrophages impact T cell function, novel assays examining the ability of macrophages to present antigen to CD8+ T cells are needed. In the present study, we have developed a robust in vitro as...

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Bibliographic Details
Main Authors: Kirsty Renfree Short, Emma eGrant, Marloes eVissers, Patrick eReading, Dimitri eDiavatopoulos, Katherine eKedzierska
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
Antigen Presentation
Macrophages
Influenza Virus
CD8+ T cell
polyfunctional T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00389/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00389/full

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