Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological literature suggest...

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Bibliographic Details
Main Authors: Kathleen A. Hershberger, John P. Rooney, Elena A. Turner, Lauren J. Donoghue, Rakesh Bodhicharla, Laura L. Maurer, Ian T. Ryde, Jina J. Kim, Rashmi Joglekar, Jonathan D. Hibshman, Latasha L. Smith, Dhaval P. Bhatt, Olga R. Ilkayeva, Matthew D. Hirschey, Joel N. Meyer
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
Mitochondrial DNA damage
Bioenergetics
Redox signaling
Mitochondrial function
Environmental toxicants
Developmental exposures
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001580

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http://www.sciencedirect.com/science/article/pii/S2213231721001580

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