Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination

Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination

The aim of this study was to investigate the potential of surface plasmon resonance (SPR) spectroscopy for the measurement of real-time ligand-binding affinities and kinetic parameters for GPR17, a G protein-coupled receptor (GPCR) of major interest in medicinal chemistry as potential target in demy...

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Bibliographic Details
Main Authors: Davide Capelli, Chiara Parravicini, Giorgio Pochetti, Roberta Montanari, Caterina Temporini, Marco Rabuffetti, Maria Letizia Trincavelli, Simona Daniele, Marta Fumagalli, Simona Saporiti, Elisabetta Bonfanti, Maria P. Abbracchio, Ivano Eberini, Stefania Ceruti, Enrica Calleri, Stefano Capaldi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Chemistry
Subjects:
GPR17
G-protein coupled receptors
SPR
ligand binding
Cangrelor
Asinex 1
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00910/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00910/full

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