AAV-mediated delivery of zinc finger nucleases targeting hepatitis B virus inhibits active replication.

AAV-mediated delivery of zinc finger nucleases targeting hepatitis B virus inhibits active replication.

Despite an existing effective vaccine, hepatitis B virus (HBV) remains a major public health concern. There are effective suppressive therapies for HBV, but they remain expensive and inaccessible to many, and not all patients respond well. Furthermore, HBV can persist as genomic covalently closed ci...

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Bibliographic Details
Main Authors: Nicholas D Weber, Daniel Stone, Ruth Hall Sedlak, Harshana S De Silva Feelixge, Pavitra Roychoudhury, Joshua T Schiffer, Martine Aubert, Keith R Jerome
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4020843?pdf=render

Internet

http://europepmc.org/articles/PMC4020843?pdf=render

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