Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease

Amyloid-β and hyperphosphorylated tau protein are known drivers of neuropathology in Alzheimer's disease. Tau in particular spreads in the brains of patients following a spatiotemporal pattern that is highly sterotypical and correlated with subsequent neurodegeneration. Novel medical imaging te...

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Bibliographic Details
Main Authors: Amelie Schäfer, Mathias Peirlinck, Kevin Linka, Ellen Kuhl, The Alzheimer's Disease Neuroimaging Initiative (ADNI)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.702975/full