PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells

PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells

Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit associated with a p85α or p85β regulatory subunit and is preferentially engag...

Full description

Bibliographic Details
Main Authors: Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
PI3K
p110δ
TCR signalling
CD4+ T cells
interactomics
CRISPR-Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.631271/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.631271/full

Similar Items