Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

α-Synuclein is a presynaptic protein that is implicated in Parkinson's and other neurodegenerative diseases. Physiologically, native α-synuclein promotes presynaptic SNARE-complex assembly, but its molecular mechanism of action remains unknown. Here, we found that native α-synuclein promotes cl...

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Bibliographic Details
Main Authors: Jiajie Diao, Jacqueline Burré, Sandro Vivona, Daniel J Cipriano, Manu Sharma, Minjoung Kyoung, Thomas C Südhof, Axel T Brunger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-04-01
Series:eLife
Subjects:
Parkinson's disease
synaptic terminal
alpha-synuclein
Online Access:https://elifesciences.org/articles/00592

Internet

https://elifesciences.org/articles/00592

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