Restriction Enzyme Based Enriched L1Hs Sequencing (REBELseq): A Scalable Technique for Detection of Ta Subfamily L1Hs in the Human Genome

Restriction Enzyme Based Enriched L1Hs Sequencing (REBELseq): A Scalable Technique for Detection of Ta Subfamily L1Hs in the Human Genome

Long interspersed element-1 retrotransposons (LINE-1 or L1) are ∼6 kb mobile DNA elements implicated in the origins of many Mendelian and complex diseases. The actively retrotransposing L1s are mostly limited to the L1 human specific (L1Hs) transcriptional active (Ta) subfamily. In this manuscript,...

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Bibliographic Details
Main Authors: Benjamin C. Reiner, Glenn A. Doyle, Andrew E. Weller, Rachel N. Levinson, Esin Namoglu, Alicia Pigeon, Emilie Dávila Perea, Cynthia Shannon Weickert, Gustavo Turecki, Deborah C. Mash, Richard C. Crist, Wade H. Berrettini
Format: Article
Language:English
Published: Oxford University Press 2020-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
rebelseq
retrotransposons
l1
l1hs
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400613

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400613

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