Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects

Sterol carrier protein-2 (SCP-2) involvement in cholesterol hydroperoxide cytotoxicity as revealed by SCP-2 inhibitor effects

Sterol carrier protein-2 (SCP-2) plays an important role in cholesterol trafficking and metabolism in mammalian cells. The purpose of this study was to determine whether SCP-2, under oxidative stress conditions, might also traffic hydroperoxides of cholesterol, thereby disseminating their cytotoxic...

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Bibliographic Details
Main Authors: Tamas Kriska, Anna Pilat, Jared C. Schmitt, Albert W. Girotti
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Journal of Lipid Research
Subjects:
oxidative stress
lipid peroxidation
lipid peroxide translocation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409514

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520409514

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