Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects

Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects

Immune evasion is an important driver of disease progression in the plasma cell malignancy multiple myeloma. Recent work highlights the potential of epigenetic modulating agents as tool to enhance anti-tumor immunity. The immune modulating effects of the combination of a DNA methyltransferase inhibi...

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Bibliographic Details
Main Authors: Lien De Beck, Sarah Melhaoui, Kim De Veirman, Eline Menu, Elke De Bruyne, Karin Vanderkerken, Karine Breckpot, Ken Maes
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:OncoImmunology
Subjects:
multiple myeloma
dna methyltransferase inhibitor
histone deacetylase inhibitor
immunogenic cell death
calreticulin
type i interferon
dendritic cell
cytotoxic t-cell
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1484981

Internet

http://dx.doi.org/10.1080/2162402X.2018.1484981

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